High-Protein Pizza Breakfast Casserole

Featured in: Weekend Blissful Bakes

This hearty morning dish combines a surprisingly simple Greek yogurt dough base with a protein-packed egg topping, turkey pepperoni, and a blend of mozzarella and cheddar cheeses. The crust comes together quickly with just flour, baking powder, and yogurt, while the egg layer gets seasoned with oregano and garlic powder for classic pizza flavors. Ready in under an hour, this makes excellent meal prep for busy weeks or serves a hungry crowd for weekend brunch. Customize with your favorite vegetables or swap the protein to suit your taste.

Updated on Mon, 09 Feb 2026 08:28:51 GMT
Freshly baked High-Protein Pizza Breakfast Casserole topped with golden melted mozzarella and savory turkey pepperoni slices. Save
Freshly baked High-Protein Pizza Breakfast Casserole topped with golden melted mozzarella and savory turkey pepperoni slices. | cocoabluff.com

Wake up to a meal that is both comforting and nutritious with this High-Protein Pizza Breakfast Casserole. This savory dish reimagines morning fuel by combining a simple Greek yogurt-based dough with fluffy eggs and zesty turkey pepperoni. It is an excellent choice for anyone needing a high-protein start to their day, offering a delicious pizza flavor profile that the whole family will enjoy. Whether you are prepping for a busy week or feeding a weekend crowd, this easy-to-make casserole is sure to satisfy.

Freshly baked High-Protein Pizza Breakfast Casserole topped with golden melted mozzarella and savory turkey pepperoni slices. Save
Freshly baked High-Protein Pizza Breakfast Casserole topped with golden melted mozzarella and savory turkey pepperoni slices. | cocoabluff.com

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The beauty of this recipe lies in its simplicity and versatility. The dough requires only a few pantry staples and yogurt, while the toppings can be customized to suit your tastes. By using low-fat milk and part-skim cheeses, it delivers a satisfyingly cheesy texture without being overly heavy, making it a smart and savory way to hit your nutritional goals.

Ingredients

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  • For the Greek Yogurt Dough:
  • 1 ½ cups (180 g) all-purpose flour
  • 2 teaspoons baking powder
  • ½ teaspoon salt
  • 1 cup (240 g) plain Greek yogurt (nonfat or 2%)
  • Toppings:
  • 8 large eggs
  • ½ cup (120 ml) low-fat milk
  • 1 cup (100 g) shredded part-skim mozzarella cheese
  • ½ cup (50 g) shredded reduced-fat cheddar cheese
  • ½ cup (60 g) turkey pepperoni slices
  • ½ teaspoon dried oregano
  • ½ teaspoon garlic powder
  • ¼ teaspoon black pepper
  • 2 tablespoons chopped fresh parsley (optional)

Instructions

Step 1
Preheat your oven to 375°F (190°C). Lightly grease a 9x13-inch (23x33 cm) sheet pan or casserole dish.
Step 2
In a medium bowl, whisk together the flour, baking powder, and salt. Add the Greek yogurt and mix with a spoon until a shaggy dough forms. Knead briefly until smooth.
Step 3
Press the dough evenly into the prepared pan, forming a thin base.
Step 4
In a large bowl, whisk together the eggs, milk, oregano, garlic powder, and black pepper until well combined.
Step 5
Pour the egg mixture evenly over the dough base.
Step 6
Sprinkle both cheeses over the eggs. Top with turkey pepperoni slices.
Step 7
Bake for 20–25 minutes, or until the eggs are set and the cheese is golden and bubbly.
Step 8
Let cool for 5 minutes, then garnish with fresh parsley if desired. Slice and serve warm.

Zusatztipps für die Zubereitung

When preparing the Greek yogurt dough, knead it just until smooth to maintain a tender crust. To ensure easy cleanup and serving, make sure the 9x13-inch pan is thoroughly greased before pressing in the dough base.

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Varianten und Anpassungen

You can easily enhance the nutrition and flavor of this dish by adding diced bell peppers, mushrooms, or spinach. For alternative protein options, substitute the turkey pepperoni with sliced chicken sausage or vegetarian pepperoni.

Serviervorschläge

Serve this savory breakfast casserole warm with a side of marinara sauce for dipping to fully embrace the pizza experience. It also pairs excellently with a fresh side salad or a portion of seasonal fruit for a complete morning meal.

A warm slice of High-Protein Pizza Breakfast Casserole revealing fluffy baked eggs and a Greek yogurt crust on a white plate. Save
A warm slice of High-Protein Pizza Breakfast Casserole revealing fluffy baked eggs and a Greek yogurt crust on a white plate. | cocoabluff.com

With its golden melted cheese and savory toppings, this High-Protein Pizza Breakfast Casserole is a satisfying dish that proves breakfast can be both healthy and exciting. Enjoy a slice and start your day with a protein-packed meal that keeps you feeling full and energized.

Recipe FAQs

Can I make this ahead of time?

Yes, this works wonderfully for meal prep. Bake it completely, let cool, then refrigerate in individual containers for up to 4 days. Reheat in the microwave for 2-3 minutes or until warmed through.

What makes the crust work with Greek yogurt?

Greek yogurt acts as a tenderizer and creates a soft, pliable dough when combined with flour and baking powder. The acidity activates the baking powder for a light texture, while the protein content helps bind everything together without needing additional fat or oil.

Can I freeze this breakfast casserole?

Absolutely. Cut into portions, wrap tightly in plastic and foil, then freeze for up to 3 months. Thaw overnight in the refrigerator before reheating. The texture remains excellent after freezing.

What vegetables work well in this dish?

Diced bell peppers, mushrooms, spinach, onions, or diced tomatoes all complement the pizza flavors. Sauté vegetables briefly before adding to prevent excess moisture from making the crust soggy.

Is this suitable for a high-protein diet?

With 22 grams of protein per serving from the Greek yogurt, eggs, and cheese, this makes an excellent choice for high-protein breakfast goals. The combination provides sustained energy while keeping carbohydrates moderate.

Can I use regular pepperoni instead of turkey?

Yes, regular pepperoni works fine, though it will add more fat and calories. You can also use chicken sausage, bacon, Canadian bacon, or make it vegetarian with plant-based alternatives.

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High-Protein Pizza Breakfast Casserole

Savory morning casserole with Greek yogurt crust, eggs, pepperoni and cheese.

Prep Duration
20 minutes
Time to Cook
25 minutes
Time Required
45 minutes
Recipe by Aubrey Gray


Skill Level Easy

Cuisine Type American

Serves 6 Portions

Dietary Details None specified

What You’ll Need

Greek Yogurt Dough

01 1 ½ cups all-purpose flour
02 2 teaspoons baking powder
03 ½ teaspoon salt
04 1 cup plain Greek yogurt, nonfat or 2%

Toppings

01 8 large eggs
02 ½ cup low-fat milk
03 1 cup shredded part-skim mozzarella cheese
04 ½ cup shredded reduced-fat cheddar cheese
05 ½ cup turkey pepperoni slices
06 ½ teaspoon dried oregano
07 ½ teaspoon garlic powder
08 ¼ teaspoon black pepper
09 2 tablespoons chopped fresh parsley, optional

Directions

Step 01

Prepare baking vessel: Preheat oven to 375°F. Lightly grease a 9x13-inch sheet pan or casserole dish.

Step 02

Combine dry ingredients: In a medium bowl, whisk together flour, baking powder, and salt.

Step 03

Form dough base: Add Greek yogurt to dry ingredients and mix with a spoon until shaggy dough forms. Knead briefly until smooth. Press dough evenly into prepared pan forming a thin base.

Step 04

Prepare egg mixture: In a large bowl, whisk together eggs, milk, oregano, garlic powder, and black pepper until well combined.

Step 05

Assemble casserole: Pour egg mixture evenly over dough base. Sprinkle both cheeses over eggs and top with turkey pepperoni slices.

Step 06

Bake until set: Bake for 20-25 minutes or until eggs are set and cheese is golden and bubbly.

Step 07

Finish and serve: Let cool for 5 minutes. Garnish with fresh parsley if desired. Slice and serve warm.

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What You Need

  • 9x13-inch sheet pan or casserole dish
  • Mixing bowls
  • Whisk
  • Measuring cups and spoons
  • Knife and cutting board

Allergy Info

Review every item to spot allergens. If unsure, reach out to a healthcare provider.
  • Contains wheat (gluten)
  • Contains eggs
  • Contains milk (dairy)
  • Check turkey pepperoni and cheese labels for potential allergens

Nutritional Breakdown (per serving)

This nutrition data is here for reference and shouldn’t substitute for your medical professional’s advice.
  • Calorie Count: 260
  • Fat content: 10 grams
  • Carbohydrates: 19 grams
  • Proteins: 22 grams

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